Currently, there is great interest in developing a tool for effective prediction of nucleosome positioning. Here, authors employed data generated by a whole genome nucleosome mapping experiment by Yuan et al. (2005), to train a support vector machine (SVM) classifier. They found that their developed program was equally predictive as one previously reported by Segal et al. (2006), which established that ~50% of positioning was determined by DNA sequence (this study was already discussed here). This, authors said, demonstrates that the proposal of a nucleosome positioning code is inconsistent. In my opinion, respect to the developed tools, clearly a detailed comparison between this and previous nucleosome positioning programs is required since they all have similar predictive abilities. Their website is here.
Peckham HE. et al. 2007 July 9. Genome Res [Epub ahead of print]
epigenetics
